PURPOSE: To provide a new compound excellent in low toxicity, having an angiotensin II-antagonistic effect and useful for prevention and improvement of hypertension, heart failure, etc.
CONSTITUTION: A compound of formula I {R1 and R2 are each a (substituted) 1 to 6C alkyl; R3 H, hydroxyl group, a (substituted) 1 to 6C alkoxy or a (substituted) phenyl-1 to 4C alkoxy; R4 is H, a (substituted) 1 to 6C alkyl or a 2 to 7C alkenyl-(substituted) 2 to 7C acyl; A is COOR5 [R is H, CH2 OCOC(CH3)3 or a protected carboxyl] or a (protected) tetrazolyl}, e.g. 3- methoxy-2,6-dimethyl-4-[N-butyryl-N-[[2'--(tetrazol-5-yl)biphenyl-4-yl] methyl]amino{9147/28}pyridine. In addition, the compound of formula I can be synthesized by reacting a compound of formula II with a compound of formula III (X is a halogen, etc.).
OGINO HIROKO
KONO KENICHI
NAGURA JUN
KONNO FUKIO
