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Title:
PREPARATION OF USEFUL GLYCYRRHIZIN SOLUTION
Document Type and Number:
Japanese Patent JPS5849310
Kind Code:
A
Abstract:

PURPOSE: To obtain the titled solution useful as an antiallergic agent, etc., by dissolving glycyrrhizin or its salt in a concentrated aqueous solution of a dissolving agent such as urea, sodium benzoate, etc. at room temperature, neutrallizing the solution with a pH-adjusting agent, and diluting with water to a specific concentration.

CONSTITUTION: Glycyrrhizin which is an active component of licorice, or its salt is dissolved in a concentrated solution of urea or sodium benzoate (dissolving agent of glycyrrhizin) at room temperature to obtain an acidic concentrated solution, which is adjusted to 6W7pH with a pH-adjusting agent (e.g. alkali carbonate) and diluted with water to a specific glycyrrhizin concentration (0.1W2.0%). Since the isotonicity of glycyrrhizin solution can be attained by the use of the above dissolving agent at a proper concentration (1W3%), it is not necessary to add a particular isotonic agent. Both dissolving agents are extremely safe and have high maximum permissible doses.

USE: Antiphlogistic agent, hepatic function improving agent, and γ-interferon- inducing agent.


Inventors:
YOKOTA SENICHI
MORI TAKEO
Application Number:
JP14660281A
Publication Date:
March 23, 1983
Filing Date:
September 17, 1981
Export Citation:
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Assignee:
MINO FUAAGEN SEIYAKU HONPO KK
International Classes:
C07H15/256; A61K9/08; A61K31/205; A61K31/7028; A61K31/7034; A61K31/704; A61K47/00; C07H15/24; (IPC1-7): A61K9/08; A61K31/205; C07H15/24
Attorney, Agent or Firm:
Hideo Nagata



 
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