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Title:
ANTI-TUMOR FAT-SOLUBLE NEW PLATINUM (IV) COMPLEX OF CYCLOHEXANEDIAMINE DERIVATIVE
Document Type and Number:
Japanese Patent JPH07101970
Kind Code:
A
Abstract:

PURPOSE: To provide a new platinum (IV) complex of a cyclohexanediamine derivative represented by a specific formula, and useful for the therapy of organ tumors including cerebral tumor because of being excellent in antitumor action and high in fat solubility.

CONSTITUTION: The complex represented by formula I {group of formula II in formula I is 1,2-cycloalkandiamine of formula III [n is 1-4; steric structure is cis(R, S-), trans-d(1S, 2S-), trans-l(1R, 2R-)], 2-aminomethylcyclohexylamine of formula IV [cis-l(R, R-), cis-d(S, S-), trans-l(R, S-), trans-d(S, R-)], 1,1- diaminomethylcyclohexane of formula V, o-phenylenediamine, ethylendiamine, propylenediamine; X is Br, I, F; B1, B2 are ligands forming an o,o-oriented 5 or 6-membered ring with platinum (IV)}.


Inventors:
KITANI YOSHINORI
KOMOTA YASUNOBU
Application Number:
JP27124793A
Publication Date:
April 18, 1995
Filing Date:
October 04, 1993
Export Citation:
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Assignee:
TANAKA PRECIOUS METAL IND
KITANI YOSHINORI
International Classes:
A61K31/28; A61K31/282; A61P35/00; C07F15/00; (IPC1-7): C07F15/00; A61K31/28