Title:
【発明の名称】セファロマンニンエポキシド、その類似体およびそれらの製造方法
Document Type and Number:
Japanese Patent JPH11501931
Kind Code:
A
Abstract:
An antitumor compound of formula (5) in which R is Ac or H, and R1, R2 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R3 is H; R1 and R2 and R3 are H; R1 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu, R2, R3 is H; R1 and R3 are H, R2 is an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R1 is H, R2 and R3 are an alkyl group such as Me, Et, Pr, i-Pr, n-Bu or t-Bu; R1 and R2 and R3 are an alkyl group Me, Et, Pr, i-Pr, n-Bu or t-Bu. Me is an abbreviation for methyl, Et is ethyl, Pr is propyl, i-Pr is isopropyl, n-Bu is n-butyl, and t-Bu is tert-butyl. Also provided by the invention is a one step method of preparing a compound of formula (5) whereby a taxane having a tiglate group attached to the side chain is contacted with an oxidizing reagent resulting in the formation of an epoxide having antitumor activity.
Inventors:
Zeng, Kung, Wai.
Murray, Christopher, Kay.
Dorgenbof, Randall, Jay.
Murray, Christopher, Kay.
Dorgenbof, Randall, Jay.
Application Number:
JP52775696A
Publication Date:
February 16, 1999
Filing Date:
March 08, 1996
Export Citation:
Assignee:
Hauser, Incorporated
International Classes:
A61K31/335; A61K31/337; A61P35/00; C07D305/14; C07D407/12; (IPC1-7): C07D407/12; A61K31/335; C07D305/14
Attorney, Agent or Firm:
Shinichi Ogawa (2 outside)