Title:
【発明の名称】化学的方法
Document Type and Number:
Japanese Patent JPH08506827
Kind Code:
A
Abstract:
PCT No. PCT/GB94/00307 Sec. 371 Date Aug. 25, 1995 Sec. 102(e) Date Aug. 25, 1995 PCT Filed Feb. 26, 1994 PCT Pub. No. WO94/19338 PCT Pub. Date Sep. 1, 1994Described herein is a process for the preparation of (1S,2R)-1,2-epoxy-1,2,3,4-tetrahydronaphthalene having the Formula (I): Formula (I) which comprises the steps of (a) hydrogenating the compound of Formula (II) to form cis-(1R, 2S)-1,2-dihydroxy-1,2,3,4-tetrahydronaphthalene having the Formula (V): (b) reacting the dihydroxy compound of Formula (V) with a sulphonyl halide of formula R1SO2Z wherein R1 is methyl, ethyl, trifluoromethyl, phenyl or p-tolyl, and Z is fluorine, chlorine, bromine or iodine to give a bis-sulphonyl ester of formula (X): and (c) treating the bis-sulphonyl ester (X) with an alkali metal carbonate or alkali metal hydroxide to give the compound of Formula (I).
Inventors:
Blacker, Andrew John
Brown, stephen martin
Boyd, Derek Raymond
Shell Drake, Gary Neil
Brown, stephen martin
Boyd, Derek Raymond
Shell Drake, Gary Neil
Application Number:
JP51873694A
Publication Date:
July 23, 1996
Filing Date:
February 16, 1994
Export Citation:
Assignee:
Zeneca Limited
International Classes:
C07C67/00; C07C69/013; C07C69/63; C07C69/773; C07C203/08; C07C203/10; C07C309/65; C07C309/66; C07C309/72; C07D301/02; C07D303/04; C07D303/14; C07D317/70; C12P7/22; (IPC1-7): C07D301/02; C07C67/00; C07C69/63; C07C69/773; C07C203/10; C07C309/65; C07C309/72; C07D303/04; C07D303/14; C07D317/70
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)