Title:
【発明の名称】ケモカインアルファ2
Document Type and Number:
Japanese Patent JP2000507101
Kind Code:
A
Abstract:
Human chemokine Alpha-2-polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are method for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, autoimmune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptides in a host.
Inventors:
Ni, Jean
Gents, Rainer El
Suh, Jeffrey Wye
Li, Hao Dong
Gents, Rainer El
Suh, Jeffrey Wye
Li, Hao Dong
Application Number:
JP53363597A
Publication Date:
June 13, 2000
Filing Date:
March 19, 1997
Export Citation:
Assignee:
HUMAN GENOME SCIENCES, INC.
International Classes:
A61K31/00; A61K38/00; A61P17/00; A61P17/02; A61P17/06; A61P29/00; A61P31/00; A61P35/00; A61P35/02; A61P37/00; A61P37/08; A61P43/00; C07K14/52; C07K16/24; C12N5/10; C12N15/09; C12N15/19; C12P21/08; C12Q1/00; C12N15/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/566; A61K48/00; (IPC1-7): C12N15/09; A61P17/02; A61P17/06; A61P29/00; A61P31/00; A61P35/00; A61P35/02; A61P37/00; A61P37/08; A61P43/00; A61K38/00; C07K16/24; C12N5/10; C12N15/02; C12P21/08; C12Q1/00; C12Q1/68; G01N33/15; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)