Title:
【発明の名称】ヒト・フォンビルブラント因子のクローニング及び製造、並びにその使用方法
Document Type and Number:
Japanese Patent JPH05506646
Kind Code:
A
Abstract:
The subject invention provides non-glycosylated, biologically active polypeptides which comprise the vWF (von Willebrand Factor) GP1b binding domain. These polypeptides may be used to inhibit platelet adhesion and aggregation in the treatment of subjects with conditions such as cerebrovascular disorders and cardiovascular disorders. This invention also provides expression plasmids encoding these polypeptides as well as methods of producing by transforming a bacterial cell and recovering such polypeptides. In addition, the subject invention provides methods of treating and preventing cerebrovascular, cardiovascular and other disorders using these polypeptides to inhibit platelet aggregation.
Inventors:
Galfinkel, Leonard
Richter, Tamar
Richter, Tamar
Application Number:
JP50611691A
Publication Date:
September 30, 1993
Filing Date:
March 01, 1991
Export Citation:
Assignee:
Biotechnology General Corporation
International Classes:
A61K38/36; A61P7/02; A61P9/08; A61P9/10; C07K14/00; C07K14/435; C07K14/47; C07K14/745; C07K14/755; A61K38/43; C12N1/21; C12N15/09; C12N15/12; C12N15/14; C12P21/00; C12P21/02; A61K38/00; C12R1/19; (IPC1-7): C07K13/00; A61K37/465; C12N1/21; C12N15/12; C12P21/00; C12P21/02
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)