Title:
【発明の名称】共配合方法およびそれらの製品
Document Type and Number:
Japanese Patent JP2003508419
Kind Code:
A
Abstract:
A coformulation of an active (preferably pharmaceutically active, for instance a COX-2 enzyme inhibitor) substance and an oligomeric or polymeric excipient, containing at least 10% of the active, between 80 and 100% of which is amorphous. The amorphous phase is stable, with respect to the crystalline phase(s), for at least three months after its preparation when stored at between 0 and 10{C. The invention also provides processes, preferably involving SEDSTM particle formation, for preparing such a coformulation.
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Inventors:
York, peter
Wilkins, Simon Anthony
Stories, Richard Anthony
Walker, Stephen Ernest
Harland, Ronald Scott
Wilkins, Simon Anthony
Stories, Richard Anthony
Walker, Stephen Ernest
Harland, Ronald Scott
Application Number:
JP2001519878A
Publication Date:
March 04, 2003
Filing Date:
August 31, 2000
Export Citation:
Assignee:
Bradford Particle Design Limited
BRISTOL-MYERS SQUIBB COMPANY
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K9/14; A61K9/16; A61K31/167; A61K31/192; A61K31/341; A61K31/375; A61K31/40; A61K31/405; A61K31/444; A61K31/522; A61K31/55; A61K45/00; A61K47/30; A61K47/32; A61K47/34; A61K47/38; A61P15/06; A61P19/02; A61P25/04; A61P29/00; A61P43/00; (IPC1-7): A61K31/405; A61K9/14; A61K31/167; A61K31/192; A61K31/341; A61K31/375; A61K31/40; A61K31/444; A61K31/522; A61K31/55; A61K45/00; A61K47/30; A61K47/32; A61K47/34; A61K47/38; A61P15/06; A61P19/02; A61P25/04; A61P29/00; A61P43/00
Attorney, Agent or Firm:
Takashi Ishida (4 others)