Title:
【発明の名称】アテローム性動脈硬化症病変の治療のためのACAT阻害剤およびMMP阻害剤の併用投与
Document Type and Number:
Japanese Patent JP2002521328
Kind Code:
A
Abstract:
This invention is the coadministration of ACAT and MMP inhibitors for the reduction of both the macrophage and smooth muscle cell component of atherosclerotic lesions, thus impairing the expansion of existing lesions and the development of new lesions and for the prevention of plaque rupture and the promotion of lesion regression in a mammal.
Inventors:
Thomas Mikel Andrew Bokan
Application Number:
JP2000560885A
Publication Date:
July 16, 2002
Filing Date:
June 18, 1999
Export Citation:
Assignee:
Warner-Lambert Company
International Classes:
A61K31/00; A61K31/17; A61K31/18; A61K31/195; A61K31/197; A61K31/198; A61K31/216; A61K31/255; A61K31/335; A61K31/343; A61K31/351; A61K31/352; A61K31/353; A61K31/357; A61K31/381; A61K31/385; A61K31/397; A61K31/403; A61K31/404; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/426; A61K31/427; A61K31/4365; A61K31/438; A61K31/44; A61K31/4427; A61K31/443; A61K31/47; A61K31/472; A61K31/54; A61K31/541; A61K31/55; A61K45/00; A61K45/06; A61P9/10; A61P43/00; C07D205/08; C07D209/18; C07D213/75; C07D213/76; C07D215/38; C07D217/04; C07D233/60; C07D233/70; C07D233/84; C07D233/88; C07D235/14; C07D239/48; C07D277/20; C07D277/30; C07D279/10; C07D307/81; C07D307/91; C07D307/94; C07D309/10; C07D311/20; C07D311/22; C07D311/58; C07D243/10; C07D313/08; C07D313/12; C07D319/06; C07D319/18; C07D333/22; C07D339/08; C07D401/12; C07D403/12; C07D405/04; C07D405/12; C07D491/113; C07D495/04; A61K; (IPC1-7): A61K45/06; A61K31/17; A61K31/197; A61K31/198; A61K31/255; A61K31/335; A61K31/343; A61K31/351; A61K31/352; A61K31/357; A61K31/381; A61K31/385; A61K31/397; A61K31/404; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/426; A61K31/427; A61K31/4365; A61K31/438; A61K31/44; A61K31/47; A61K31/54; A61K31/55; A61P9/10; A61P43/00; C07D205/08; C07D209/18; C07D213/75; C07D213/76; C07D215/38; C07D217/04; C07D233/60; C07D233/70; C07D233/84; C07D233/88; C07D235/14; C07D239/48; C07D243/10; C07D277/30; C07D279/10; C07D307/81; C07D307/91; C07D307/94; C07D309/10; C07D311/20; C07D311/22; C07D311/58; C07D313/08; C07D313/12; C07D319/06; C07D319/18; C07D333/22; C07D339/08; C07D401/12; C07D403/12; C07D405/04; C07D405/12; C07D491/113; C07D495/04
Attorney, Agent or Firm:
Chika Takagi (2 outside)