Title:
【発明の名称】安定なビオチン化生体分子の組成物及び方法
Document Type and Number:
Japanese Patent JP2000514778
Kind Code:
A
Abstract:
Stable compositions containing biotinylated molecules, such as enzymes, are provided. The compositions include a biotinylated biomolecule, a biomolecule protectant, a buffer, a bulking agent selected from one or more water soluble, nonionic polymers and preferably a terminal sterilization protectant. The compositions can be utilized either as aqueous solutions or preferably in dried form, e.g., as a lyophilized, powder cake. They have applicability in any case where avidin/biotin technology is used and are particularly important as compositions containing a thrombin-like enzyme, e.g., for preparation of a fibrin monomer and fibrin monomer-based fibrin sealants.
Inventors:
Burton, Stephen Jay.
Person, James Sea.
Edwardson, Peter A., Dee.
Menzies, Alan
Person, James Sea.
Edwardson, Peter A., Dee.
Menzies, Alan
Application Number:
JP51821497A
Publication Date:
November 07, 2000
Filing Date:
October 24, 1996
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
G01N33/53; A61L2/00; C07D495/04; C07K14/75; C07K17/06; C12N9/00; C12N11/06; C12P21/00; G01N33/531; G01N33/543; (IPC1-7): C07D495/04; C07K17/06; C12N9/00; C12N11/06; C12P21/00; G01N33/53; G01N33/531
Domestic Patent References:
| JPH06199685A | 1994-07-19 | |||
| JPH05331071A | 1993-12-14 | |||
| JPH06321805A | 1994-11-22 | |||
| JPH07194378A | 1995-08-01 |
Attorney, Agent or Firm:
Takashi Ishida (4 others)