Title:
【発明の名称】化合物
Document Type and Number:
Japanese Patent JP2000513380
Kind Code:
A
Abstract:
There are described therapeutically active compounds or salts or solvates thereof, hydrolysable in human or animal blood to compounds with reduced therapeutic activity. There is also described a method of identifying a compound capable of providing a therapeutic effect at a target site within a human or animal body with reduced systemic potency to said body comprising evaluating the half-life of said compound in the presence of human serum paraoxonase. Suitable compounds have a half-life of less than 1 hour.
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Inventors:
Keith, Big Adyke
Richard, Martin, Angel
Panner Yotis, Alexandro, Procopio
Rosanne, mary, farrell
Usha, Buoy Ramesh
Duncan, Stuart, Holmes
Richard, Martin, Angel
Panner Yotis, Alexandro, Procopio
Rosanne, mary, farrell
Usha, Buoy Ramesh
Duncan, Stuart, Holmes
Application Number:
JP50627799A
Publication Date:
October 10, 2000
Filing Date:
June 26, 1998
Export Citation:
Assignee:
GLAXO GROUP LTD.
International Classes:
A61K31/341; A61K31/573; A61K31/58; A61K31/585; A61P1/00; A61P1/04; A61P5/44; A61P11/00; A61P11/06; C07D307/58; A61P29/00; A61P37/08; C07J3/00; C07J5/00; C07J17/00; C07J31/00; C07J33/00; C07J71/00; C12Q1/44; (IPC1-7): C07J31/00; A61K31/58; A61P1/04; A61P5/44; A61P11/06; A61P29/00; C07J17/00; C07J33/00
Attorney, Agent or Firm:
Kazuo Sato (3 others)