Title:
【発明の名称】タンパク質-タンパク質相互作用を阻害するための化合物と方法
Document Type and Number:
Japanese Patent JP2002508398
Kind Code:
A
Abstract:
Compounds having molecular weights of less than 1500 daltons that non-covalently interact with target proteins and covalently bond to target proteins at amino acid side chains that are not part of enzyme active sites, in which covalently bound portions of the compounds sterically block the binding of the target proteins to other proteins, are disclosed. The compounds react with forward reaction rates at least 100 times faster than the forward reaction rates at which the compounds bond to the side chains of the corresponding free amino acids under physiological conditions. Compositions including these compounds and methods for preparing these compounds are also disclosed.
Inventors:
Way Jeffrey Sea.
Application Number:
JP2000539163A
Publication Date:
March 19, 2002
Filing Date:
December 02, 1998
Export Citation:
Assignee:
Way Jeffrey Sea.
International Classes:
G01N33/50; A61K45/00; C07B61/00; C07C57/58; C07C205/37; C40B30/04; C40B40/04; G01N33/15; G01N33/53; G01N33/566; G01N33/68; (IPC1-7): C07C57/58; A61K45/00; C07B61/00; C07C205/37; G01N33/15; G01N33/50; G01N33/53; G01N33/566
Attorney, Agent or Firm:
Shimizu Hatsushi (1 person outside)