NEW MATERIAL:Antibiotic MMB-2040A shown by the formula I and antibiotic BBM-2040B shown by the formula II.
USE: An antibiotic and an antitumor agent. Inhibiting activities of Gram-positive bacteria and acid-fast bacteria, further inhibiting growth of tumor (e.g., leukemia P 338 of mouse).
PROCESS: A bacterium[e.g., strain of Streptomyces sp. J 576-99 (ATCC 39143)] belonging to the genus Streptomyces, capable of producing BBM-2040 is cultivated under submerged aerobic conditions in an aqueous nutrient medium containing a source capable of assimilating carbon and nitrogen until a substantial amount of BBM-2040 is produced in the medium, and the use of methanol is avoided in the following extraction and chromatography purification operations, to give a compound shown by the formula II in a demethanol state. When methanol is used as an extraction solvent or eluting solvent, a compound shown by the formula I , an adduct of the compound shown by the formula II with methanol, is obtained.
OOKUMA HIROAKI
KONISHI MASATAKA
MIYAGI TAKEO
KAWAGUCHI HIROSHI
| JPS57131791A | 1982-08-14 |
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