Title:
【発明の名称】コンフォメーションおよびトポロジータンパク質の調節
Document Type and Number:
Japanese Patent JP2003517313
Kind Code:
A
Abstract:
Methods and compositions are provided for identifying novel conformers of proteins not known to exist as different conformers. By using chimeric genes replacing a native signal sequence with a different signal sequence resulting in the production of a conformer, one can compare the native protein with the product of the chimeric gene. Where the conformations are different, the different protein may be used for production of antibodies, elucidation of mechanisms associated with the native and different conformer protein, assays for the presence of the different conformer in physiological samples, identification of compounds specifically binding to the conformer, particularly drugs, etc. Where the formation of the conformer is associated with a diseased state, the conformer may be used in screens to identify compounds as drug candidates.
Inventors:
Lingappa, Bishwanus Earl.
Lutsky, Thomas Dee.
Hedge, Ramanungan S.
Lutsky, Thomas Dee.
Hedge, Ramanungan S.
Application Number:
JP2001545853A
Publication Date:
May 27, 2003
Filing Date:
December 15, 2000
Export Citation:
Assignee:
The Regents of the University of California
International Classes:
G01N33/53; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/62; C12N15/63; C12Q1/02; G01N30/88; G01N33/68; A61K39/00; (IPC1-7): C12N15/09; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/02; G01N30/88; G01N33/53
Attorney, Agent or Firm:
Takashi Ishida (4 others)