Title:
【発明の名称】シクロアルキル置換グルタルアミド降圧剤
Document Type and Number:
Japanese Patent JPH05504146
Kind Code:
A
Abstract:
Compounds of formula (I), wherein A completes a 5 or 6 membered carbocyclic ring which may be saturated or monounsaturated; Y is an alkylene group of from 1 to 9 carbon atoms; R<1> is H or (C1-C4)alkyl; R and R<4> are H, (C1-C6)alkyl, (C3-C7)cycloalkyl, benzyl, or an alternative biolabile ester-forming group; R<2> is defined to include a range of substituent groups including (C1-C6)alkoxy, (C1-C4)alkoxy-(C1-C6)alkoxy and various substituted-alkyl, amino, substituted amino, aryl and heterocyclyl substituents linked directly or by O, S(O)n, NR<6>, CO or CONR<6> wherein R<6> is H, (C1-C4)alkyl or aryl(C1-C4)alkyl and n is 0, 1 or 2; R<3> is a group of formula (II), wherein R<13> is H, halo, 4-OH, 4-(C1-C6 alkoxy), 4-(C3-C7 cycloalkoxy), 4-(C2-C6 alkenyloxy), 4-[(C1-C6 alkoxy)carbonyloxy], 4-[(C3-C7 cycloalkyloxy)carbonyloxy], or 3-(C1-C4 alkyl)SO2NH-; and R<14> is H, (C1-C4)alkyl, (C1-C4)alkoxy, (C2-C6)alkanoyl or halo; or R<3> is a group of formulae (III) or (IV), wherein said groups may optionally be substituted in the fused benzene ring by (C1-C4)alkyl, (C1-C4)alkoxy, OH, halo or CF3; or are atriopeptidase inhibitors or utility in the treatment of hypertension and heart failure.
Inventors:
Danil Wicks, John Christopher
James, Keith
Alan John, Corris
Brown, david
James, Keith
Alan John, Corris
Brown, david
Application Number:
JP50397391A
Publication Date:
July 01, 1993
Filing Date:
February 14, 1991
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
A61K31/195; A61K31/215; A61K31/35; A61K31/351; A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61K31/445; A61P9/04; A61P9/12; A61P43/00; C07C233/63; C07C235/40; C07C237/22; C07C237/24; C07C237/36; C07C237/42; C07C247/12; C07C271/22; C07C271/66; C07C273/18; C07C311/06; C07C317/44; C07C317/48; C07C323/52; C07C323/60; C07D209/14; C07D211/46; C07D211/58; C07D211/74; C07D231/56; C07D233/60; C07D295/14; C07D295/145; C07D309/12; C07D521/00; C07C275/22; (IPC1-7): A61K31/195; A61K31/215; A61K31/35; A61K31/40; A61K31/415; A61K31/445; C07C233/63; C07C235/40; C07C237/22; C07C237/42; C07C247/12; C07C311/06; C07C323/52; C07D209/14; C07D211/46; C07D211/74; C07D231/56; C07D233/60; C07D295/14; C07D309/12
Domestic Patent References:
| JPH02124862A | 1990-05-14 |
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)