Title:
【発明の名称】野生型p53遺伝子の欠失の検出
Document Type and Number:
Japanese Patent JP3434817
Kind Code:
B2
Abstract:
Methods and kits are provided for assessing mutations and/or loss of the p53 gene in human tumors. Both deletion mutations and point mutations in p53 are observed in the same human tumor cells and these mutations are clonal within the cells of the tumor. Loss of wild-type p53 genes is responsible for neoplastic progression.
Inventors:
Bad Bogerstin
Suzanne Jay Mebaker
Eric Earl Fearon
Janice M Nigro
Suzanne Jay Mebaker
Eric Earl Fearon
Janice M Nigro
Application Number:
JP6952690A
Publication Date:
August 11, 2003
Filing Date:
March 19, 1990
Export Citation:
Assignee:
THE JOHNS HOPKINS UNIVERSITY
International Classes:
C12N15/09; A61B10/00; A61K38/00; A61K48/00; A61P35/00; C12Q1/44; C12Q1/48; C12Q1/68; G01N33/574; (IPC1-7): C12Q1/68; C12N15/09
Other References:
ＥＭＢＯ Ｊｏｕｒｎａｌ，４（５）（１９８５），ｐｐ．１２５１−１２５５
Ｇｅｎｅ，７０（１）（１９８８），ｐｐ．２４５−２５２
Ｊｏｕｒｎａｌ ｏｆ Ｐａｔｈｏｌｏｇｙ，１５７（３）（１９８９），ｐｐ．１９３−１９９
Ｎｅｗ Ｅｎｇｌａｎｄ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎｅ，３１９（９）（１９８８），ｐｐ．５２５−５３２
Ｇｅｎｅ，７０（１）（１９８８），ｐｐ．２４５−２５２
Ｊｏｕｒｎａｌ ｏｆ Ｐａｔｈｏｌｏｇｙ，１５７（３）（１９８９），ｐｐ．１９３−１９９
Ｎｅｗ Ｅｎｇｌａｎｄ Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎｅ，３１９（９）（１９８８），ｐｐ．５２５−５３２
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)