Title:
【発明の名称】エンドセリン拮抗剤
Document Type and Number:
Japanese Patent JPH10509706
Kind Code:
A
Abstract:
A compound of formula (I), in which: R1 is lower alkyl, cyclo(lower)alkyl, optionally substituted aryl, optionally substituted heterocyclic group, cyclo(lower)alkyl(lower)alkyl, or ar(lower)alkyl; R2 is hydrogen, hydroxy or protected hydroxy; R3 is lower alkyl, aryl, ar(lower)alkyl or optionally substituted heterocyclic(lower)alkyl; R4 is carboxy, protected carboxy or lower alkylsufonylcarbamoyl; R5 is hydrogen or lower alkyl; R6 is hydrogen or heterocyclic group; A is a single bond or lower alkylene, and Ar is optionally substituted aryl, or pharmaceutically acceptable salts thereof, having endothelin antagonistic activity.
Inventors:
Masahiro Kaoru
Yoshimitsu Tatsuya
Hitoshi Sawada
Chiyoshi Kasahara
Murata Masayoshi
Keiji Hemi
Yoshimitsu Tatsuya
Hitoshi Sawada
Chiyoshi Kasahara
Murata Masayoshi
Keiji Hemi
Application Number:
JP51592096A
Publication Date:
September 22, 1998
Filing Date:
November 13, 1995
Export Citation:
Assignee:
Fujisawa Pharmaceutical Co., Ltd.
International Classes:
A61K31/357; A61K31/36; A61K31/38; A61K31/403; A61K31/404; A61K31/405; A61K31/415; A61P1/00; A61P9/00; A61P9/12; A61P11/00; A61P43/00; C07D209/20; C07D317/60; C07D405/06; C07D405/12; C07D405/14; C07D409/12; C07D411/06; (IPC1-7): C07D209/20; A61K31/36; A61K31/38; A61K31/405; A61K31/415; C07D317/60; C07D405/06; C07D405/14; C07D411/06