Title:
【発明の名称】アシル-L-カルニチンとγ-ヒドロキシ酪酸とのエステル
Document Type and Number:
Japanese Patent JP2930749
Kind Code:
B2
Abstract:
The esters of acyl L-carnitines with gamma-hydroxybutyric acid in the form of pharmacologically acceptable salts of formula (I) wherein X<-> is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate or in the form of inner salts of formula (I min ) wherein R is a straight or branched acyl group having from 2 to 5 carbon atoms, such as e.g. acetyl, propionyl, n-butyryl, isobutyryl and isovaleryl, are active in inhibiting neuronal degeneration (as it occurs in Alzheimer's senile dementia and Parkinson's disease) and in the treatment of coma.
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Inventors:
MARIA ORUNEERA CHINCHI
DOMENIKO MISHICHI
KURAUJIO KABAZA
NAZARENO SUKAFUETSUTA
DOMENIKO MISHICHI
KURAUJIO KABAZA
NAZARENO SUKAFUETSUTA
Application Number:
JP3917491A
Publication Date:
August 03, 1999
Filing Date:
February 08, 1991
Export Citation:
Assignee:
SHIGUMA TAU IND PHARM RYUNICHI SPA
International Classes:
A61P25/00; A61P25/28; A61K31/22; C07C219/22; C07C229/22; (IPC1-7): C07C229/22; A61K31/22
Domestic Patent References:
| JP8295616A | ||||
| JP710820A | ||||
| JP3173854A | ||||
| JP2169555A | ||||
| JP62272983A | ||||
| JP6163639A | ||||
| JP55167262A | ||||
| JP61501006A |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)