Title:
【発明の名称】細胞外/上皮増殖因子HCABA58X
Document Type and Number:
Japanese Patent JP2000508894
Kind Code:
A
Abstract:
The present invention discloses a novel cDNA isolated from human osteoclastoma tissue which encodes a novel polypeptide identified herein as Extracellular/Epidermal Growth Factor HCABA58X owing in part to the presence in its amino acid sequence of epidermal growth factor (EGF) domains characteristic of the EGF family of polypeptides. Also provided are procedures for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides. Also disclosed are antagonists against such polypeptides and their uses. Also disclosed are diagnostic assays for detecting altered levels of the polypeptides of the present invention and mutations in the nucleic acid sequences which encode such polypeptides.
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Inventors:
Olsen, Henrik S.
Ruben, Stephen M.
Ruben, Stephen M.
Application Number:
JP53614197A
Publication Date:
July 18, 2000
Filing Date:
April 10, 1996
Export Citation:
Assignee:
Human Genome Sciences, Inc.
International Classes:
C12N15/09; A61K31/00; A61K38/22; A61K39/395; A61K45/00; A61K48/00; A61P43/00; C07K14/47; C07K14/485; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12Q1/02; C12Q1/68; G01N33/53; A61K38/00; (IPC1-7): C12N15/09; A61K38/22; A61K39/395; A61K45/00; A61K48/00; A61P43/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/02; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Shusaku Yamamoto