Title:
【発明の名称】ヘルペスウイルス粒子及びワクチン
Document Type and Number:
Japanese Patent JPH06509466
Kind Code:
A
Abstract:
In addition to virions, herpesvirus-infected cells produce non-infectious particles, termed L-particles, which consist of tegument surrounded by envelope but lack the nucleocapsid. L-particles of a herpesvirus can be prepared substantially free of infectious virions, e.g. by allowing an appropriate temperature-sensitive mutant to replicate at its non-permissive temperature, and such L-particles are useful as a component of a vaccine against the herpesvirus. They can also be prepared to contain a foreign protein or peptide, by use of a recombinant herpesvirus.
Inventors:
McLochlan, Jiyoung
Rixon, Fraser Jiyoung
Rixon, Fraser Jiyoung
Application Number:
JP50867292A
Publication Date:
October 27, 1994
Filing Date:
May 07, 1992
Export Citation:
Assignee:
Medical Research Council
International Classes:
A61K31/34; A61K31/343; A61K31/357; A61K31/19; A61K31/36; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61K31/41; A61K31/415; A61K31/44; A61K31/443; A61K31/66; A61K39/245; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P13/02; A61P15/00; A61P31/12; A61P31/22; A61P43/00; C07C13/465; C07C23/34; C07C25/22; C07C33/38; C07C35/32; C07C39/23; C07C43/188; C07C43/21; C07C45/71; C07C49/84; C07C61/20; C07C61/39; C07C62/06; C07C62/14; C07C62/30; C07C62/32; C07C62/34; C07C67/31; C07C67/343; C07C69/734; C07C69/738; C07C69/757; C07C211/42; C07C211/57; C07C235/82; C07C323/00; C07D209/04; C07D213/60; C07D233/56; C07D249/02; C07D257/02; C07D257/04; C07D275/02; C07D277/22; C07D307/79; C07D317/50; C07D317/60; C07D333/10; C07D405/08; C07D405/12; C07D407/08; C07F9/30; C07F9/38; C12N7/00; C12N15/09; C12N15/869; C07C59/00; (IPC1-7): C12N7/00; A61K39/245; C12N15/86
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)