Title:
【発明の名称】複素環アントラサイクリノン誘導体
Document Type and Number:
Japanese Patent JP2002506065
Kind Code:
A
Abstract:
A compound of formula (1) wherein R1 is hydrogen, hydroxy, a group of formula OR5 wherein R5 is C1-C6 alkyl, C2-C6 alkenyl or C3-C8 cycloalkyl, halogen, amino which may be unsubstituted or mono or disubstituted by C1-C6 alkyl, C2-C6 alkenyl, aralkyl, acyl or trifluoroacetyl; R2 is hydrogen, hydroxy, a group NR6R7 wherein R6 and R7 independently represent hydrogen, an optionally substituted C1-C6 alkyl, C2-C6 alkenyl, C3-C8 cycloalkyl or, taken together with the nitrogen atom, represent an optionally substituted C3-C8 heterocyclic ring; R3 is hydrogen, hydroxy, R4 is a 2-substituted thiazolyl or imidazolyl system and the pharmaceutically acceptable salt thereof, is useful in the treatment of amyloidosis. Processes for the preparation and pharmaceutical compositions are also described.
Inventors:
Mantegani, Sergio
Gabriel Zla
Bandeiera, Tetiano
Lansen, Jacqueline
Balaji, Mario
Gabriel Zla
Bandeiera, Tetiano
Lansen, Jacqueline
Balaji, Mario
Application Number:
JP2000535633A
Publication Date:
February 26, 2002
Filing Date:
March 04, 1999
Export Citation:
Assignee:
Farmacia e Appzyon Esset Pear
International Classes:
A61K31/65; A61P25/00; A61P25/28; C07D233/88; C07D277/20; C07D277/38; C07D277/40; C07D277/42; C07D417/04; (IPC1-7): C07D277/42; A61K31/65; A61P25/00; A61P25/28; C07D233/88; C07D277/38
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)