Title:
【発明の名称】一酸化窒素シンターゼの阻害物質としてのヘキサヒドロ-5-イミノ-1,4-ヘテロアゼピン誘導体
Document Type and Number:
Japanese Patent JP3188715
Kind Code:
B2
Abstract:
Disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders, including neurodegenerative disorders, disorders of gastrointestinal motility and inflammation. These diseases and disorders include hypotension, septic shock, toxic shock syndrome, hemodialysis, IL-2 therapy such as in cancer patients, cachexia, immunosuppression such as in transplant therapy, autoimmune and/or inflammatory indications including sunburn, eczema or psoriasis and respiratory conditions such as bronchitis, asthma, oxidant-induced lung injury and acute respiratory distress (ARDS), glomerulonephritis, restenosis, inflammatory sequelae of viral infections, myocarditis, heart failure, atherosclerosis, osteoarthritis, rheumatoid arthritis, septic arthritis, chronic or inflammatory bowel disease, ulcerative colitis, Crohn's disease, systemic lupus erythematosis (SLE), ocular conditions such as ocular hypertension, retinitis and uveitis, type 1 diabetes, insulin-dependent diabetes mellitus and cystic fibrosis.
Inventors:
Caldwell, Charles G
William K. Hugman
McCos, Malcolm
Shear, Sirenitz K
Siyan Karan, Kozandalaman
Fulman, Carla El
William K. Hugman
McCos, Malcolm
Shear, Sirenitz K
Siyan Karan, Kozandalaman
Fulman, Carla El
Application Number:
JP51753197A
Publication Date:
July 16, 2001
Filing Date:
October 28, 1996
Export Citation:
Assignee:
Merck End Company, Inc.
International Classes:
A61K31/55; A61K31/554; A61P1/00; A61P1/14; A61P3/10; A61P9/00; A61P9/02; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/02; A61P13/12; A61P15/00; A61P17/04; A61P17/06; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P27/06; A61P29/00; A61P35/00; A61P37/00; A61P37/02; A61P37/06; A61P43/00; C07D243/06; C07D243/08; C07D267/08; C07D267/10; C07D267/16; C07D281/04; C07D281/06; C07D281/10; C07D401/00; C07D403/00; C07D405/00; C07D409/00; C07D413/00; C07D417/00; C07D487/04; C07D495/04; C07D498/04; C07D513/04; (IPC1-7): C07D267/10; A61K31/55; A61P1/00; A61P1/14; A61P3/10; A61P9/02; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/04; A61P17/06; A61P25/16; A61P25/28; A61P27/06; A61P29/00; A61P37/02; A61P37/06; A61P43/00
Attorney, Agent or Firm:
Yoshio Kawaguchi (1 person outside)