Title:
【発明の名称】高流量中空糸膜
Document Type and Number:
Japanese Patent JP3392141
Kind Code:
B2
Abstract:
Semipermeable membranes are disclosed for purifying aqueous biological fluids. The membranes are particularly suitable for purifying extracorporeal blood via hemodialysis. The membranes, preferably configured as hollow fibers, are made from a hydrophilic polymeric material, preferably cellulose acetate. Features of the membranes include an ultrafiltration coefficient (KuF) of about 15 to about 55 mL/hr/mmHg/m<2> (thus termed "high-flux" type membranes), a urea mass transfer coefficient (KoV(urea)) of at least 38x10<-><3> cm/min, and a ratio of KoV(urea)/KuF of at least 2.5x10<-><3>. Hollow fibers of such membranes suitable for hemodialysis have a lumen diameter of about 175 to about 210 mu m and a wall thickness of about 10 to about 35 mu m. According to disclosed methods for making the membranes, a melt comprising about 32 to about 40% w/w cellulose acetate, about 5 to about 10% w/w glycerine, and about 50 to about 67% w/w polyethylene glycol is extruded to make hollow fibers; the fibers are cooled, cold-stretched, water-leached, and replasticized using a glycerine solution.
Inventors:
Altin Anders
Fernandez Ben
Elsen Raymond
Ruthius Keith
Silver Laris
Washington George
Fernandez Ben
Elsen Raymond
Ruthius Keith
Silver Laris
Washington George
Application Number:
JP51230694A
Publication Date:
March 31, 2003
Filing Date:
November 10, 1993
Export Citation:
Assignee:
Baxter International Inc.
International Classes:
A61M1/16; A61M1/18; B01D39/18; B01D63/02; C08B30/04; B01D65/00; B01D65/02; B01D67/00; B01D69/02; B01D69/08; B01D71/16; (IPC1-7): B01D69/02; B01D69/08; B01D71/16; C08B30/04
Domestic Patent References:
| JP62250215A | ||||
| JP5442420A | ||||
| JP523555A |
Attorney, Agent or Firm:
Shusaku Yamamoto