【発明の名称】普遍的なドナー細胞及びキメラ性哺乳類宿主のための相同性組換え

Title:

【発明の名称】普遍的なドナー細胞及びキメラ性哺乳類宿主のための相同性組換え

Document Type and Number:

Japanese Patent JPH04501510

Kind Code:

A

Abstract:

Homologous recombination is employed to inactivate genes, particularly genes associated with MHC antigenes. Particularly, the beta 2-microglobulin gene is inactivated for reducing or eliminating Class I MHC antigenes. The resulting cells may be used as universal donors. In addition, embryonic stem cells may be modified by homologous recombination for use in producing chimeric or transgenic mammalian hosts.

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Inventors:

Kucharapati, Lajuez.
Coller, Beverly H.
Smithies, Oliver

Application Number:

JP51131990A

Publication Date:

March 19, 1992

Filing Date:

July 25, 1990

Export Citation:

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Assignee:

Cell Genesis, Incorporated

International Classes:

A01K67/027; C07H21/04; C07K14/74; C12N5/10; C12N15/00; C12N15/09; C12N15/85; (IPC1-7): A01K67/027; C07H21/04; C12N5/10; C12N15/11; C12N15/63

Attorney, Agent or Firm:

Aoki Akira (2 outside)

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