Title:
【発明の名称】ヒトGタンパク質結合レセプター
Document Type and Number:
Japanese Patent JPH11503012
Kind Code:
A
Abstract:
Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
Inventors:
Lee
Khao, Lian
Ni, Gian
Gents, Rainer
Baltic, Carol Jay.
Sutton, Granger J., The Third
Rosen, Craig A.
Khao, Lian
Ni, Gian
Gents, Rainer
Baltic, Carol Jay.
Sutton, Granger J., The Third
Rosen, Craig A.
Application Number:
JP52930296A
Publication Date:
March 23, 1999
Filing Date:
March 30, 1995
Export Citation:
Assignee:
Human Genome Sciences, Inc.
International Classes:
G01N33/53; A61K31/70; A61K38/00; A61K39/395; A61K48/00; A61P1/04; A61P1/14; A61P3/04; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P13/02; A61P15/00; A61P25/00; A61P37/08; A61P43/00; C07H21/04; C07K14/705; C07K14/715; C07K16/28; C12N5/06; C12N5/10; C12N15/09; C12P21/02; C12Q1/68; (IPC1-7): C12N15/09; A61K31/70; A61K38/00; A61K39/395; A61K48/00; C07K14/705; C07K16/28; C12N5/10; C12P21/02; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Shusaku Yamamoto