Title:
【発明の名称】sel-12の同定およびその使用
Document Type and Number:
Japanese Patent JPH11512611
Kind Code:
A
Abstract:
This invention provides an isolated nucleic acid molecule encoding a SEL-12. This invention further provides an isolated nucleic acid molecule which encodes a mutated SEL-12. This invention also provides an isolated nucleic acid molecule which encodes a mutated SEL-12, wherein the mutated SEL-12 contains at least one of the following: position 115 is a leucine, position 132 is an arginine, position 215 is a glutamic acid, position 229 is a valine, position 254 is a valine, position 255 is a valine, position 371 is a valine, position 387 is a tyrosine, position 104 is an isoleucine or position 204 is a valine. This invention further provides different uses of these nucleic acid molecules. This invention also provides different sel-12 mutants and transgenic animals which carry wild-type or mutated sel-12.
Inventors:
Greenwold, Iba
Levitan, Diane
Levitan, Diane
Application Number:
JP51376197A
Publication Date:
November 02, 1999
Filing Date:
September 27, 1996
Export Citation:
Assignee:
The Trustees of Columbia University in the City of New York
International Classes:
A01K67/027; A01K67/033; A61K31/00; A61K31/70; A61K31/7088; A61K48/00; A61P25/28; C07H21/02; C07K14/435; C07K16/18; C12N1/21; C12N5/10; C12N15/00; C12N15/09; C12N15/12; C12N15/84; C12P21/02; A61K38/00; C12R1/91; (IPC1-7): C12N15/09; A01K67/027; A01K67/033; C07K14/435; C07K16/18; C12N1/21; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Takehiko Suzue (4 outside)