【発明の名称】p38のインヒビター - VERTEX PHARMACEUTICALS INCORPORATED

Title:

【発明の名称】p38のインヒビター

Document Type and Number:

Japanese Patent JP2003528084

Kind Code:

A

Abstract:

The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli, having the formula (III), or tautomers thereof or pharmaceutically acceptable salts thereof, wherein: each of Q1 and Q2 are independently selected from 5-6 membered aromatic carbocyclic or heterocyclic ring systems, or 8-10 membered bicyclic ring systems comprising aromatic carbocyclic rings, aromatic heterocyclic rings or a combination of an aromatic carbocyclic ring and an aromatic heterocyclic ring. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

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Inventors:

Saliculo, Francesco
Bemis, Guy
Ebinder, Gotas

Application Number:

JP2001568907A

Publication Date:

September 24, 2003

Filing Date:

March 22, 2001

Export Citation:

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Assignee:

VERTEX PHARMACEUTICALS INCORPORATED

International Classes:

C07D487/04; A61K31/4418; A61K31/519; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P5/14; A61P7/00; A61P7/02; A61P7/04; A61P7/06; A61P7/10; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P21/04; A61P25/00; A61P25/04; A61P25/16; A61P25/28; A61P29/00; A61P29/02; A61P31/04; A61P31/12; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D213/75; C07D489/04; (IPC1-7): C07D213/75; A61K31/4418; A61K31/519; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P5/14; A61P7/00; A61P7/02; A61P7/04; A61P7/06; A61P7/10; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P19/10; A61P21/04; A61P25/00; A61P25/04; A61P25/16; A61P25/28; A61P29/00; A61P29/02; A61P31/04; A61P31/12; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D487/04

Foreign References:

WO1999058502A1	1999-11-18
WO1998027098A1	1998-06-25
WO1999032110A1	1999-07-01
WO1998052941A1	1998-11-26

Attorney, Agent or Firm:

Shusaku Yamamoto (2 outside)

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