Title:
【発明の名称】細胞内ビタミンD結合タンパク質
Document Type and Number:
Japanese Patent JP2002514898
Kind Code:
A
Abstract:
The invention relates to the discovery and purification of novel intracellular vitamin D binding proteins (IDBPs) and the isolation of polynucleotide sequences encoding the proteins. IDBPs are of interest because they mediate the vitamin D resistance, i.e., insensitivity, observed in new world primates. IDBPs are distinct from the vitamin D receptor and other intracellular receptors, e.g. estrogen receptor. One aspect of the invention is to provide purified IDBPs as pharmaceutical compositions to affect steroid hormone activity. Another aspect of the invention provides polynucleotides encoding the IDBPs of the invention for use in altering the expression of IDBPs. Yet another aspect of the invention is to provide assays for the detection or screening of therapeutic compounds that interfere with the interaction between IDBP and vitamin D (or other ligands that bind to IDBP), and the use of such compounds as pharmaceutical compositions.
Inventors:
Adams, John S.
Application Number:
JP52875297A
Publication Date:
May 21, 2002
Filing Date:
February 12, 1997
Export Citation:
Assignee:
Cedars-Sinai Medical Center
International Classes:
C07K14/47; C07K14/57; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12Q1/02; G01N33/15; G01N33/50; G01N33/566; A61K38/00; (IPC1-7): C12N15/09; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12Q1/02; G01N33/15; G01N33/50; G01N33/566
Attorney, Agent or Firm:
Shusaku Yamamoto