Title:
【発明の名称】LTA▲下4▼ハイドロラーゼ阻害剤、医薬組成物及び使用方法
Document Type and Number:
Japanese Patent JPH10512542
Kind Code:
A
Abstract:
The present invention provides compounds of the formula Ar1-Q-Ar2-Y-R-Z and pharmaceutically acceptable salts thereof wherein Ar1 and Ar2 are optionally substituted aryl moieties, Z is an optionally substituted nitrogen-containing moiety which may be an acyclic, cyclic or bicyclic amine or an optionally substituted monocyclic or bicyclic nitrogen-containing heteroaromatic moiety; Q is a linking group capable of linking two aryl groups; R is an alkylene moiety; Y is a linking moiety capable of linking an aryl group to an alkylene moiety and wherein Z is bonded to R through a nitrogen atom. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as psoriasis, ulcerative colitis, IBD and asthma.
Inventors:
Chandra Kumar, Nizar, Samuel
Chen, Barbara, Baosheng
Claire, Michael
Desai, Bipin Chandra, Nanub Hai
Dojulik, Stephen, Wakefield
Doctor, stephan, herman
Gashyki, Alan, Frank
Hark, richard, arthur
Lian, Chi Dean
Miyashiro, Julie, Marion
Penning, Thomas, Dale
Russell, Mark, Andrew
Yu, Stella, Siu-Twee
Chen, Barbara, Baosheng
Claire, Michael
Desai, Bipin Chandra, Nanub Hai
Dojulik, Stephen, Wakefield
Doctor, stephan, herman
Gashyki, Alan, Frank
Hark, richard, arthur
Lian, Chi Dean
Miyashiro, Julie, Marion
Penning, Thomas, Dale
Russell, Mark, Andrew
Yu, Stella, Siu-Twee
Application Number:
JP51260996A
Publication Date:
December 02, 1998
Filing Date:
October 10, 1995
Export Citation:
Assignee:
G.D.Searle & Company
International Classes:
C07D295/08; A61K31/135; A61K31/138; A61K31/192; A61K31/195; A61K31/197; A61K31/215; A61K31/216; A61K31/34; A61K31/341; A61K31/343; A61K31/357; A61K31/36; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61K31/415; A61K31/4184; A61K31/435; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/445; A61K31/4465; A61K31/4468; A61K31/4535; A61K31/454; A61K31/46; A61K31/495; A61K31/496; A61K31/535; A61K31/5355; A61K31/5375; A61K31/695; A61P29/00; A61P43/00; C07D207/14; C07D207/16; C07D209/12; C07D211/58; C07D211/62; C07D213/38; C07D215/12; C07D235/08; C07D277/24; C07D295/18; C07D307/42; C07D307/81; C07D307/85; C07D311/58; C07D317/54; C07D333/16; C07D401/12; C07D405/12; C07D409/12; C07D471/04; C07D473/08; C07D491/052; C07D491/107; (IPC1-7): A61K31/195; A61K31/135; A61K31/215; A61K31/34; A61K31/36; A61K31/40; A61K31/415; A61K31/435; A61K31/445; A61K31/495; A61K31/535; A61K31/695; C07D207/14; C07D207/16; C07D209/12; C07D211/58; C07D211/62; C07D213/38; C07D215/12; C07D277/24; C07D295/08; C07D295/18; C07D307/42; C07D307/81; C07D307/85; C07D311/58; C07D317/54; C07D333/16; C07D401/12; C07D405/12; C07D409/12; C07D473/08; C07D491/052; C07D491/107
Attorney, Agent or Firm:
Akira Asamura (3 outside)