Title:
【発明の名称】大環状ラクトン化合物及びその製法
Document Type and Number:
Japanese Patent JP3061863
Kind Code:
B2
Abstract:
This invention provides a process for producing a macrocyclic lactone compound, which comprises cultivating Actinoplanes sp. FERM BP-3832, in the presence of L-proline, L-hydroxyproline or L-nipecotic acid, and then isolating a macrocylic lactone compound from the fermentation broth. The compounds produced by this process include a compound of the following formula:The present invention also relates to a pharmaceutical composition comprising the same, which is useful as immunosuppressive, antimycotic, antitumor agent or the like.
Inventors:
Hiroyuki Nishida
Yuji Yamauchi
Taisuke Inagaki
Yasuhiro Kojima
Nakao Kojima
Yuji Yamauchi
Taisuke Inagaki
Yasuhiro Kojima
Nakao Kojima
Application Number:
JP51586995A
Publication Date:
July 10, 2000
Filing Date:
October 13, 1995
Export Citation:
Assignee:
Pfizer Pharmaceuticals Co., Ltd.
International Classes:
A61K31/40; A61K31/401; A61K31/445; A61K31/70; A61K35/00; A61P31/04; A61P35/00; A61P37/06; B65G43/00; C07D209/00; C07D273/00; B65B57/02; C07D311/00; C07D498/18; C07H19/01; C12P1/06; C12P17/18; G01B11/26; G05B19/02; G05B19/05; G05D3/00; G05D3/12; C12R1/045; C07D; (IPC1-7): C07D498/18; A61K31/40; A61P31/04; A61P35/00; A61P37/06; C12P1/06; C12P17/18
Attorney, Agent or Firm:
Hiroshi Kobayashi