【発明の名称】マンガン(▲II▼)キレート

Japanese Patent JP3003940

B2

A process is provided for the preparation of Mn(II) chelates for use as contrast agents in magnetic resonance imaging, said process comprising reacting insoluble manganese (II) oxide with an aqueous suspension comprising a molar equivalent or molar excess of an insoluble protonated chelating compound conveniently at a temperature of from 20 to 50 DEG C. When the reaction is carried out with a protonated chelating agent in the absence of base, a precipitate of the protonated Mn(II) chelate is formed. A low osmolarity Mn(II) chelate solution can be formed from the precipitates by dissolving them in an aqueous solution of base. When the initial chelate forming reaction is carried out in a solution containing a molar equivalent or excess of base, a low osmolarity solution of the Mn(II) chelate is directly formed with most chelating agents. The Mn(II) chelate precipitates and low osmolarity solutions formed by the above processes are also aspects of this invention.

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Lockrage, Scott
Caerieris, william
Jean Amyson, Jean

JP50997489A

January 31, 2000

September 26, 1989

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A61K49/06; C07C229/16; A61K49/00; C07D213/66; C07D257/02; C07D273/00; C07F9/6558; C07F13/00; (IPC1-7): C07F13/00; A61K49/00

JP6341468A
JP635077A

【文献】米国特許4322361(US,A)

Chika Takagi (2 outside)

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