Title:
【発明の名称】21―デスオキシプレドニゾロン―17―エステルの製造法
Document Type and Number:
Japanese Patent JPH07116222
Kind Code:
B2
Abstract:
A process for preparing 21-desoxyprednisolone 17-esters of formula (IV) is disclosed. The process comprises reacting a prednisolone 17 alpha ,21-cyclic orthoester with an acid in a 40-60% lower alcohol solution to produce a prednisolone 17-ester, sulfonylating the prednisolone 17-ester into a prednisolone 17-ester 21-sulfonate, and reacting the sulfonate with an alkali metal iodide in methyl ethyl ketone in the presence of a lower fatty acid to produce the compound of formula (IV). The process ensures economical industrial production of high purity 21-desoxyprednisolone 17-esters, an excellent local anti-inflammatory medicine, in a high yield by simple procedures.
Inventors:
Kuriyama Tadatoshi
Masaki Ogawa
Susumu Sato
Taido
Kuraishi Tadayuki
Masaki Ogawa
Susumu Sato
Taido
Kuraishi Tadayuki
Application Number:
JP27918889A
Publication Date:
December 13, 1995
Filing Date:
October 26, 1989
Export Citation:
Assignee:
SSP Co., Ltd.
International Classes:
C07J5/00; C07J7/00; C07J21/00; C07J31/00; C07J75/00; (IPC1-7): C07J75/00; C07J5/00
Domestic Patent References:
| JP5359655A |
Other References:
【文献】米国特許3856956(US,A)
【文献】米国特許3639434(US,A)
【文献】米国特許3980680(US,A)
【文献】米国特許3639434(US,A)
【文献】米国特許3980680(US,A)
Attorney, Agent or Firm:
Miyuki Ariga (2 outside)