Title:
【発明の名称】キメラ抗体の産生方法
Document Type and Number:
Japanese Patent JP2714786
Kind Code:
B2
Abstract:
A process for the production of a chimeric antibody, comprising: a) preparing a replicable expression vector including a suitable promoter operably linked to a DNA sequence comprising a first part which encodes at least the variable region of the heavy or light chain of an Ig molecule and a second part which encodes at least part of a second protein; b) if necessary, preparing a replicable expression vector including a suitable promoter operably linked to a DNA sequence which encodes at least the variable region of a complementary light or heavy chain respectively of an Ig molecule; c) transforming an immortalised mammalian cell line with the or both prepared vectors; and d) culturing said transformed cell line to produce the chimeric antibody; chimeric antibodies produced by this process; and plasmids and transformed cell lines used in the process.
Inventors:
Neuberger, Michael, Samuel
Rabits, Terence, Howard
Rabits, Terence, Howard
Application Number:
JP50394085A
Publication Date:
February 16, 1998
Filing Date:
September 03, 1985
Export Citation:
Assignee:
Celtec Limited
International Classes:
A61K39/00; A61K39/395; C07H21/04; C07K14/00; C07K16/00; C12N15/02; C07K16/44; C07K16/46; C07K19/00; C12N5/00; C12N5/10; C12N15/00; C12N15/09; C12N15/13; C12N15/62; C12P21/00; C12P21/08; G01N33/531; G01N33/563; G01N33/577; C12R1/91; (IPC1-7): C12P21/00; C12N15/09
Domestic Patent References:
| JP5843926A | ||||
| JP54145289A |
Other References:
【文献】Proc.Natl.Acad.Sci.USA 81(1984)P.3273~3277
Attorney, Agent or Firm:
Toru Sakamoto