PURPOSE: To obtain the subject compound useful as a medicine having calmodulin-dependent cGMP-PDE inhibitory activity.
CONSTITUTION: A compound of formula I [ring A is benzene ring, pyridine ring or cyclohexane ring; ring B is pyridine ring, imidazole ring or pyrimidine ring; rings A and B are bound to each other with two shared atoms, such as C and N; R1 is NR4R5 (R4 and R5 are each H, a lower alkyl, acyl, (protected) carboxyl, or together form a (substituted) ring in combination with the N atom bound thereto) or heteroaryl which may bear substituent(s) containing 1-2N atom(s); R2 is H, formula II (R8 is (protected) carboxyl or a (protected) tetrazolyl) or halogen; R3 is H or formula III (R6 and R7 are each H, halogen, a lower alkoxy or together form methylenedioxy or ethylenedioxy)] or a salt thereof, e.g. 2-chloro-4-(3,4-methylenedioxybenzyl)amino-6-(pyrazol-1-yl)quinazoline.
WATANABE NOBUHISA
ADACHI HIDEYUKI
KODAMA KOTARO
ISHIHARA HIROKI
SAEKI TAKAO
SODA SHIGERU