Title:
【発明の名称】三環式化合物の製造方法
Document Type and Number:
Japanese Patent JP2809509
Kind Code:
B2
Abstract:
PCT No. PCT/EP94/00147 Sec. 371 Date Jan. 4, 1996 Sec. 102(e) Date Jan. 4, 1996 PCT Filed Jan. 19, 1994 PCT Pub. No. WO94/17074 PCT Pub. Date Aug. 4, 1994 (I) (III) A process for preparing a compound of formula (I) or a phamaceutically-acceptable salt thereof, comprising: 1) reacting a compound. of formula (III), in which R is a straight or branched chain alkyl having from one to four carbon atoms, with an alkali metal hydroxide in an aqueous medium at a temperature of about 80 DEG to 120 DEG C. and time of about 20 to 100 hours to form a reaction product; 2) cyclizing the reaction product of step 1) with formic acid and formaldehyde to form a formiate compound; and 3) neutralizing the formiate compound of step 2) with an aqueous base.
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Inventors:
KARUPUFU EMU
TORASARUDEI AARU
TORASARUDEI AARU
Application Number:
JP51665494A
Publication Date:
October 08, 1998
Filing Date:
January 19, 1994
Export Citation:
Assignee:
FUAIZAA INC
International Classes:
A61K31/535; A61P31/04; C07C243/18; C07C243/28; C07D215/58; C07D498/06; (IPC1-7): C07D498/06; C07D215/58
Domestic Patent References:
| JPS60204476A | 1985-10-16 |
Other References:
Ｌｉｅｂｉｇｓ Ａｎｎａｌｅｎ ｄｅｒ Ｃｈｅｍｉｅ．Ｎｏ．１０，１９８７，Ｐ８７１〜８７９
Attorney, Agent or Firm:
Kazuo Shamoto (4 outside)