Title:
【発明の名称】2’,2’-ジフルオロシチジン類の選択的単離法
Document Type and Number:
Japanese Patent JP2899576
Kind Code:
B2
Abstract:
The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2'-deoxy-2',2'-difluoronucleosides in about a 1:1 α/β anomeric ratio, and processes for selectively isolating β-2'-deoxy-2',2'-difluorocytidine, or an organic or inorganic acid addition salt thereof, from the 1:1 α/β mixture.
Inventors:
TAASEN CHO
PERII KURAAKU HIISU
ROORENSU EDOWAADO PATAASON
PERII KURAAKU HIISU
ROORENSU EDOWAADO PATAASON
Application Number:
JP22795297A
Publication Date:
June 02, 1999
Filing Date:
August 25, 1997
Export Citation:
Assignee:
IIRAI RIRII ANDO CO
International Classes:
A61K31/365; A61K31/70; A61K31/7024; C07H1/06; A61K31/7042; A61K31/7052; A61K31/7056; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61P35/00; C07D307/32; C07D307/33; C07H7/02; C07H13/08; C07H19/056; C07H19/06; C07H19/067; C07H19/12; C07H19/16; C07H19/167; (IPC1-7): C07H19/06
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)