Title:
【発明の名称】レーザー誘起蛍光減衰分光分析の方法と装置
Document Type and Number:
Japanese Patent JP2001509589
Kind Code:
A
Abstract:
Methods and devices for Laser Induced Fluorescence Attenuation (LIFAS) Spectroscopy, including, in particular, methods and devices for the detection of ischemia and hypoxia in biological tissue. The LIFAS method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample. The methods and devices of the inventions are particularly well-suited for determining the wavelength-dependent attenuation of a sample and using the attenuation to restore the intrinsic laser induced fluorescence of the sample. In turn, the attenuation and intrinsic laser induced fluorescence can be used to determine a characteristic of interest, such as the ischemic or hypoxic condition of biological tissue.
More Like This:
Inventors:
Shihada, Rams, Yi
Marmalellis, Basilis, Zette
Grundfest, Warren, S
Marmalellis, Basilis, Zette
Grundfest, Warren, S
Application Number:
JP2000502389A
Publication Date:
July 24, 2001
Filing Date:
June 09, 1998
Export Citation:
Assignee:
CEDARS-SINAI MEDICAL CENTER
International Classes:
A61B5/00; A61B5/145; A61B5/1455; A61B10/00; G01N21/27; G01N21/49; G01N21/64; (IPC1-7): G01N21/27; A61B5/145; A61B10/00; G01N21/64
Attorney, Agent or Firm:
Akira Asamura (3 outside)