Title:
【発明の名称】エルゴリンのN-メチル誘導体の製法
Document Type and Number:
Japanese Patent JPH0667936
Kind Code:
B2
Abstract:
A process for preparing an N-methyl derivative of ergoline of formula: in which R1 denotes a carboxy or alkoxycarbonyl group in which the alkyl portion contains 1 to 4 carbon atoms, R2 denotes a hydrogen atom or a methoxy group and R3 denotes a hydrogen atom or R2 and R3 together form a direct bond, or in which R1 denotes a hydroxymethyl group, R2 denotes a hydrogen atom or a methoxy group and R3 denotes a hydrogen atom, which comprises methylating an ergoline derivative of formula: in which R1, R2 and R3 are defined as above, with methyl carbonate in the presence of a basic agent, in an apolar aprotic solvent in the present of a phase transfer catalyst.
Inventors:
Christian jeerbe
Application Number:
JP16097086A
Publication Date:
August 31, 1994
Filing Date:
July 10, 1986
Export Citation:
Assignee:
Loan-Pro-Santo
International Classes:
B01J31/00; B01J31/02; C07B61/00; C07D457/02; C07D457/04; C07D457/08; (IPC1-7): C07D457/04; B01J31/02; C07B61/00
Attorney, Agent or Firm:
Heiyoshi Odashima
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