Title:
【発明の名称】キラルエステルの製造方法
Document Type and Number:
Japanese Patent JP2003512035
Kind Code:
A
Abstract:
The present invention relates to a process for preparing a chiral ester expressed in formula (100) by mixing and reacting: a ketone of formula (4); a ruthenium complex selected from the group consisting of compounds (1, 2 and 3) expressed in formula (1) to (3) to activate hydrogenation of said ketone to a racemic alcohol and racemization of said racemic alcohol; a lipase to acylate selectively one of enantiomers of said racemic alcohol; a hydride donor group to supply a hydride group to said ruthenium complex; and an acyl donor group to supply acyl group to said lipase. In formula (1) wherein Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Y9, Y10, Y11, and Y12 are independentlya hydrogen atom or C1-C5 alkyl group; and X is Br, Cl or I. In formula (2) wherein Y1, Y2, Y3, Y4, Y5, Y6 Y7, Y8, Y9, Y10, Y11, and Y12 are independently a hydrogen atom or C1-C5 alkyl group; and X is Br, Cl, or I. In formulae (3), (4), and (100) wherein R<1>, R<2>, and R<3> are, independently, optionally substituted alkyl, optionally substituted aryl or optionally substituted cyclyoalkyl group and R<1> and R<2>, R<1> and R<3>, and R<2> and R<3> can be cyclized each other, where said substituent of alkyl, aryl and cycloalkyl is a hetero atom such as a halogen atom and a cyano group.
Inventors:
Park Zeuk
Kim Manju
Woo Jung Huang
John Hyun Min
Kim Manju
Woo Jung Huang
John Hyun Min
Application Number:
JP2001531776A
Publication Date:
April 02, 2003
Filing Date:
October 18, 2000
Export Citation:
Assignee:
Samsung Fine Chemicals Company Limited
Pohang University of Science and Technology
Pohang University of Science and Technology
International Classes:
C07C67/00; C07B61/00; C07C29/143; C07C31/125; C07C31/135; C07C33/20; C07C33/46; C07C35/23; C07C41/26; C07C43/23; C12P7/62; (IPC1-7): C12P7/62; C07C29/143; C07C31/125; C07C31/135; C07C33/20; C07C33/46; C07C35/23; C07C41/26; C07C43/23
Attorney, Agent or Firm:
Kyosei International Patent Office