Title:
【発明の名称】キノリンカルボン酸誘導体の製造方法
Document Type and Number:
Japanese Patent JP2693988
Kind Code:
B2
Abstract:
The invention relates to a new process for the preparation of compounds of general formula (I) (wherein R<1> stands for phenyl being optionally substituted by 1 or 2 halogen atoms, or a group of the general formula CH2CR<6>R<7>R<8> (wherein R<6>, R<7> and R<8> stand for hydrogen or halogen); R<2> stands for piperazinyl or 4-methyl-piperazinyl; R<3> stands for hydrogen or fluorine) and pharmaceutically acceptable salts thereof which comprises reacting a compound of general formula (II) (wherein R stands for halogen or an aliphatic acyloxy group containing 2 to 6 carbon atoms or an aromatic acyloxy group containing 7 to 11 carbon atoms, R<4> stands for fluorine or chlorine) with a piperazine derivative of general formula (III) (wherein R<5> stands for hydrogen or methyl) or a salt thereof and subjecting the compound of general formula (IV) thus obtained (wherein R, R<1>, R<2> and R<3> are as stated above) to hydrolysis after or without isolation and if desired converting the compound of general formula (I) thus obtained into a salt thereof or setting free the same from its salt. The compounds of general formula (I) are known antibacterial agents. The advantage of the process of the present invention is that it makes the desired compounds of general formula (I) available in a simple manner, with high yields and in a short reaction time.
Inventors:
Hermek's, Istvan
Ceres Tree, Geza
Basbali, Lele
Holbass, Agnes
Baroque, Maria
Retori, peter
Sipos, Judith
Payor, Anico
Ceres Tree, Geza
Basbali, Lele
Holbass, Agnes
Baroque, Maria
Retori, peter
Sipos, Judith
Payor, Anico
Application Number:
JP50432888A
Publication Date:
December 24, 1997
Filing Date:
May 20, 1988
Export Citation:
Assignee:
Quinoin Giogi Suzel S Begui Szechi Thermekek Giara Art Tea.
International Classes:
C07D215/56; C07F5/02; (IPC1-7): C07D215/56
Domestic Patent References:
| JP59122470A |
Other References:
【文献】欧州公開131839(EP,A1)
Attorney, Agent or Firm:
Akira Asamura (1 person outside)