Title:
【発明の名称】アンピシリンの回収法
Document Type and Number:
Japanese Patent JPH11502832
Kind Code:
A
Abstract:
Process for the recovery of ampicillin from a mixture containing ampicillin and 6-aminopenicillic acid (6-APA), in which a mixture of ampicillin and 6-APA, with a pH higher than 7, which apart from any solid ampicillin being present is homogeneous at a pH between 7 and 8.5, is subjected to a pH lowering till a pH lower than 8.2 is reached, and the solid substance present is recovered. The process is in particular suitable to be applied to the reaction mixture which is obtained after the enzymatic acylation reaction of 6-APA with a phenylglycidine derivative as acylation agent. Pure ampicillin can thus be recovered in a simple way.
Inventors:
Boesten, Wilhelms, Hvartas, Joseph
Moody, Harold, Monro
Ruth, Eric, Cornelis
Moody, Harold, Monro
Ruth, Eric, Cornelis
Application Number:
JP52920896A
Publication Date:
March 09, 1999
Filing Date:
March 25, 1996
Export Citation:
Assignee:
Chem Farm Buoy.
International Classes:
C07D499/00; C07D499/18; C12P37/04; (IPC1-7): C07D499/18
Attorney, Agent or Firm:
Mitsuo Matsui