Title:
【発明の名称】真核細胞系でのヒトプラスミノーゲンの発現方法および物質
Document Type and Number:
Japanese Patent JPH05500748
Kind Code:
A
Abstract:
Recombinant human plasminogen may be produced in invertebrate cells or in other eukaryotic cells lacking a site-specific plasminogen activator by expression of a vector including a gene encoding human plasminogen. Human plasminogen may thus be expressed without degradation by plasmin produced by intracellular plasminogen activators found in mammalian cells. The plasminogen product of such expression may be purified, acylated, complexed with acylated or non-acylated fibrinolytic enzymes and formulated into pharmaceutical compositions for use in thrombolytic therapy.
Inventors:
Castellino, Francis Jay.
White Fleet-Smith, Joan, Elle.
Rosen, Elliott Dee.
McLinden, James H.
White Fleet-Smith, Joan, Elle.
Rosen, Elliott Dee.
McLinden, James H.
Application Number:
JP50779290A
Publication Date:
February 18, 1993
Filing Date:
April 26, 1990
Export Citation:
Assignee:
The University of Notre Dame du Lac
International Classes:
A61K38/48; A61K38/46; A61K38/54; A61P7/02; C07K14/00; C07K14/315; C07K16/18; C07K16/40; C07K19/00; C12N9/68; C12N9/70; C12N9/99; C12N15/09; C12N15/12; C12N15/85; C12N15/866; A61K38/00; (IPC1-7): A61K37/47; A61K37/54; C07K13/00; C12N9/68; C12N9/70; C12N15/57
Attorney, Agent or Firm:
Yoshihiro Tsunoda