Title:
【発明の名称】D―アミノ酸を含むβ―アミロイドペプチド凝集のモジュレーター
Document Type and Number:
Japanese Patent JP2001500852
Kind Code:
A
Abstract:
Compounds that medlate natural beta -amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a beta -amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-viline. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a beta -amyloid peptide, preferably a retro-inverso isomer of A beta 17-21. In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups include cyclic, heterocyclic, polycyclic and branched alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an alkyl amide group, an aryl amide group or a hydroxy group. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amylaidogenic diseases using the compounds of the invention, are also disclosed.
Inventors:
Findies, Mark A.
Geoffer, Malcolm El.
Gary, Mussoo
Signer, Ethan Earl.
Wakefield, james
Morin Oaks, Susan
Gin, joseph
Lee, Junja
Kelly michael
Komalpanicci, Sonya
Alicomendel, Christopher See.
Phillips, Kasulin
Hayward, Neil Jay.
Geoffer, Malcolm El.
Gary, Mussoo
Signer, Ethan Earl.
Wakefield, james
Morin Oaks, Susan
Gin, joseph
Lee, Junja
Kelly michael
Komalpanicci, Sonya
Alicomendel, Christopher See.
Phillips, Kasulin
Hayward, Neil Jay.
Application Number:
JP51191498A
Publication Date:
January 23, 2001
Filing Date:
August 27, 1997
Export Citation:
Assignee:
Praices Pharmaceuticals, Inc.
International Classes:
A61K38/00; A61K38/17; A61K51/00; A61P25/28; C07K5/083; C07K5/103; C07K5/107; C07K7/06; G01N33/68; C07K14/47; (IPC1-7): C07K5/103; A61K38/00; A61K51/00; A61P25/28; C07K5/083; C07K5/107; C07K7/06; G01N33/68
Attorney, Agent or Firm:
Motohiro Kurauchi (1 outside)