Title:
【発明の名称】プロテイン・チロシン・ホスファターゼ(PTPases)のモジュレーター
Document Type and Number:
Japanese Patent JP2002506073
Kind Code:
A
Abstract:
The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTP alpha , LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.
Inventors:
Henrik Sunne, Andersen
Todd Kevin, Jones
Holsworth, Daniel Dale
Todd Kevin, Jones
Holsworth, Daniel Dale
Application Number:
JP2000535646A
Publication Date:
February 26, 2002
Filing Date:
March 11, 1999
Export Citation:
Assignee:
Novo Nordisk Actiesel Scab
Ontogen Corporation
Ontogen Corporation
International Classes:
C07D237/28; A61K31/385; A61K31/429; A61K31/4355; A61K31/4365; A61K31/437; A61K31/4375; A61K31/47; A61K31/472; A61K31/495; A61K31/4985; A61K31/502; A61K31/5025; A61K31/517; A61K31/519; A61P3/06; A61P3/10; A61P5/10; A61P7/02; A61P11/06; A61P17/06; A61P19/10; A61P25/00; A61P25/18; A61P25/28; A61P31/04; A61P35/00; A61P37/06; A61P37/08; C07C233/56; C07C237/22; C07D207/34; C07D209/08; C07D209/14; C07D213/79; C07D213/80; C07D215/38; C07D217/22; C07D231/40; C07D237/30; C07D239/42; C07D239/557; C07D239/86; C07D241/44; C07D261/08; C07D271/10; C07D333/38; C07D333/66; C07D333/68; C07D409/04; C07D409/06; C07D413/04; C07D471/04; C07D487/04; C07D491/048; C07D495/04; C07D495/10; C07D495/14; C07D513/04; C07D239/54; (IPC1-7): C07D495/04; A61K31/385; A61K31/429; A61K31/4355; A61K31/4365; A61K31/437; A61K31/4375; A61K31/47; A61K31/472; A61K31/495; A61K31/4985; A61K31/5025; A61K31/519; A61P3/06; A61P3/10; A61P5/10; A61P7/02; A61P11/06; A61P17/06; A61P19/10; A61P25/00; A61P25/18; A61P25/28; A61P31/04; A61P35/00; A61P37/06; A61P37/08; C07D215/38; C07D217/22; C07D237/28; C07D237/30; C07D239/86; C07D241/44; C07D471/04; C07D487/04; C07D491/048; C07D513/04
Attorney, Agent or Firm:
Takashi Ishida (4 others)