Title:
【発明の名称】N-置換ペプチジルニトリル
Document Type and Number:
Japanese Patent JP2003533506
Kind Code:
A
Abstract:
Compounds of the formula (I), wherein R1 is aryl or biaryl; R2 is aryl-lower alkyl, biaryl-lower alkyl, benzo-fused cycloalkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C2-C7-alkyl in which C2-C7-alkyl is interrupted by Y; Y is O, S, SO, SO2, CO or NR6; R3 is hydrogen or lower alkyl; or R2 and R3 combined are C2-C7-alkylene or C2-C7-alkylene interrupted by Y; R4 is hydrogen or lower alkyl; R5 is hydrogen, optionally substituted lower alkyl, aryl-lower alkyl, biaryl-lower alkyl, cycloalkyl-lower alkyl, bicycloalkyl-lower alkyl, aryloxy-lower alkyl, or aryl-C2-C7-alkyl in which C2-C7-alkyl is interrupted by Y; R6 is hydrogen, lower alkyl or aryl-lower alkyl; and pharmaceutically acceptable salts thereof, which are useful as cysteine cathepsin inhibitors.
Inventors:
Scott Douglas Kauen
Paul David Greenspan
Leslie Wyton McChoir
Ruben Albert Tomasi
John Henry Van Dather
Paul David Greenspan
Leslie Wyton McChoir
Ruben Albert Tomasi
John Henry Van Dather
Application Number:
JP2001584225A
Publication Date:
November 11, 2003
Filing Date:
May 14, 2001
Export Citation:
Assignee:
Novartis Actien Gezel Shaft
International Classes:
C07D295/10; A61K31/277; A61K31/341; A61K31/365; A61K31/381; A61K31/40; A61K31/4035; A61K31/405; A61K31/41; A61K31/4172; A61K31/423; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/4406; A61K31/4409; A61P9/10; A61P11/06; A61P11/08; A61P19/02; A61P19/10; A61P29/00; A61P31/00; A61P35/00; A61P35/04; A61P37/02; A61P43/00; C07C255/29; C07C255/58; C07C311/19; C07D209/08; C07D209/18; C07D209/20; C07D209/46; C07D209/48; C07D213/56; C07D213/79; C07D233/54; C07D233/64; C07D257/04; C07D263/58; C07D277/20; C07D277/30; C07D277/56; C07D277/62; C07D295/192; C07D307/54; C07D307/56; C07D307/68; C07D307/79; C07D307/88; C07D333/24; C07D333/36; C07D333/38; C07D333/40; C07D333/60; C07D405/12; C07D409/12; C07D471/04; (IPC1-7): C07C255/29; A61K31/277; A61K31/341; A61K31/365; A61K31/381; A61K31/40; A61K31/4035; A61K31/405; A61K31/41; A61K31/4172; A61K31/423; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/4406; A61K31/4409; A61P9/10; A61P11/06; A61P11/08; A61P19/02; A61P19/10; A61P29/00; A61P31/00; A61P35/00; A61P35/04; A61P37/02; A61P43/00; C07D209/08; C07D209/18; C07D209/20; C07D209/46; C07D209/48; C07D213/56; C07D213/79; C07D233/64; C07D257/04; C07D263/58; C07D277/56; C07D277/62; C07D295/10; C07D307/54; C07D307/56; C07D307/88; C07D333/24; C07D333/36; C07D333/40; C07D333/60; C07D405/12; C07D409/12; C07D471/04
Domestic Patent References:
| JPH05310667A | 1993-11-22 |
Foreign References:
| WO1999024460A2 | 1999-05-20 | |||
| WO2000049007A1 | 2000-08-24 | |||
| WO2000055125A2 | 2000-09-21 | |||
| WO2001049288A1 | 2001-07-12 |
Attorney, Agent or Firm:
Kaoru Aoyama (3 people outside)