Title:
【発明の名称】TGF-βスーパーファミリーの新規のメンバーであるGDF―15の神経保護特性
Document Type and Number:
Japanese Patent JP2002543841
Kind Code:
A
Abstract:
The present invention relates to a transforming growth factor-beta (TGF-beta)-like protein which is derived from neurons and glial cells, and which has a neurotrophic effect on dopaminergic (DAergic) neurons, to nucleic acids coding for the protein, to a vector containing the nucleic acids, to host organisms containing the nucleic acids or the vector, to antibodies directed against the protein, to methods for the production of the nucleic acids, the vector or the protein, to a pharmaceutical composition for the treatment of neurodegenerative disorders in mammals and to a diagnostic kit for the detection of said disorders.
Inventors:
Unsicker Claus
Creeglestein Kerstin
Creeglestein Kerstin
Application Number:
JP2000618457A
Publication Date:
December 24, 2002
Filing Date:
May 16, 2000
Export Citation:
Assignee:
Biofarm Gezer Shaft Tour Biotechnology Schen Entwick Lung und Tsum Felt Reeve von Pharmaka Mbeha
International Classes:
G01N33/53; A61K31/7088; A61K35/76; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P25/00; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P31/04; A61P43/00; C07K14/495; C07K16/22; C07K16/24; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/19; C12P19/34; C12P21/02; C12Q1/68; (IPC1-7): C12N15/09; A61K31/7088; A61K35/76; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P25/00; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P31/04; A61P43/00; C07K14/495; C07K16/22; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P19/34; C12P21/02; C12Q1/68; G01N33/53
Attorney, Agent or Firm:
Eiji Saegusa (8 others)