Title:
【発明の名称】新規16,17-アセタ-ル置換アンドロスタン-17β-カルボン酸エステル
Document Type and Number:
Japanese Patent JPH0762028
Kind Code:
B2
Abstract:
The invention refers to compounds having anti- inflammetory activity characterized by the formulaor a stereoisomeric component thereof, in which formula the 1,2-position is saturated or is a double bandX, is selected from hydrogen, fluorine, chlorine and bromineX2 is selected from hydrogen, fluorine, chlorine and bromineR1 is selected from hydrogen or a straight or branched hydrocarbon chain having 1-4 carbon atomsR2 is selected from hydrogen or straight and branched hydrocarbon chains having 1-10 carbon atoms andR3 is selected fromY is O or SR4 is selected from hydrogen, straight or branched hydrocarbon chains having 1-10 carbon atoms or from phenylR5 is selected from hydrogen or methyl andR6 is selected from hydrogen, straight or branched, saturated or unsaturated hydrocarbon chains having 1-10 carbon atoms, an alkyl group substituted by at least one halogen atom, a heterocyclic ring system containing 3-10 atoms in the ring system, -(CH2)m CH(CH2)n (m=0,1,2; n=2,3,4,5,6), phenyl or benzyl groups which are unsubstituted or substituted by one or more alkyl, nitro, carboxy, alkoxy, halogen, cyano, carbalkoxy or trifluoromethyl group(s), provided that when R2 is hydrogen R1 is methyl.The invention also refers to a process and intermediates for the preparation of these compounds, a pharmaceutical preparation containing one of the compounds and a method for the treatment of inflammatory conditions.
Inventors:
Paul Hokan Anderson
Pelle Teure Anderson
Bengt Ingemal Axelson
Brolu Arne Thalen
Jan Villiam Trovast
Pelle Teure Anderson
Bengt Ingemal Axelson
Brolu Arne Thalen
Jan Villiam Trovast
Application Number:
JP7567786A
Publication Date:
July 05, 1995
Filing Date:
April 03, 1986
Export Citation:
Assignee:
Actie Boraget Draco
International Classes:
A61P5/38; A61P29/00; A61K31/58; C07F3/00; C07J1/00; C07J5/00; C07J71/00; (IPC1-7): C07J71/00; A61K31/58
Domestic Patent References:
| JP5745200A | ||||
| JP533714B2 |
Other References:
【文献】米国特許4198336(US,A)
Attorney, Agent or Firm:
Chika Takagi (2 outside)
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