Title:
【発明の名称】新規アリ-ル酢酸誘導体
Document Type and Number:
Japanese Patent JPS61500915
Kind Code:
A
Abstract:
A compound having a potentially inhibitory effect on 15-hydroxy-prostaglandin dehydrognase (PGDH) and having the formulain whichR1 and R2 are hydrogen or lower alkyl;R3 is hydrogen, lower alkyl or substituted or unsubstituted phenyl;R4, R5 and Re are hydrogen, halogen, lower alkyl, lower alkoxy, cyano, carboxy or nitro; at least one of the groups R4 to R6 being hydrogen;R7 to R11 are hydrogen, halogen, cyano, lower alkyl, trifluoromethyl, lower alkoxy, hydroxy, lower acyl, lower alkoxycarbonyl, N,N,-diloweralkyl-aminocarbonyl or N,N-loweralkylene-aminocarbonyl; and R8 to R10 may in addition be carboxy; at least two of R7 to R11 always being hydrogen; and -A- is -CO-, -CH2-CO-, -CH=CH-, -CH=CH-CO- or corresponding groups in which a hydrogen atom is replaced by a lower alkyl group.The invention comprises also lactones of those compounds in which R1 is hydrogen, and salts of those compounds which contain at least one carboxy group.
Inventors:
Arkback, Karl Hubert
Akbatsk, Tamara
Niklen, Alf Sigard
Akbatsk, Tamara
Niklen, Alf Sigard
Application Number:
JP50049985A
Publication Date:
May 08, 1986
Filing Date:
January 18, 1985
Export Citation:
Assignee:
Mold Pharmacia Arbe
International Classes:
C07C69/73; A61K31/00; A61K31/235; C07C59/00; C07C59/52; C07C59/56; C07C59/64; C07C59/90; C07C65/19; C07C65/28; C07C65/40; C07C67/00; C07C69/00; C07C69/616; C07C69/94; C07C201/00; C07C205/56; C07C231/00; C07C235/42; C07C235/46; C07C235/84; C07C253/00; C07D307/83; (IPC1-7): C07C59/52; A61K31/19; A61K31/215; A61K31/235; A61K31/275; A61K31/365; C07C59/56; C07C59/64; C07C59/90; C07C65/19; C07C65/28; C07C65/40; C07C69/73; C07C69/94; C07C79/46; C07C103/76; C07C121/75; C07C121/76; C07D307/83
Foreign References:
| US3828093A | 1974-08-06 |
Attorney, Agent or Firm:
Yoshio Kawaguchi (4 outside)