Title:
【発明の名称】新規ソホロース脂質、それらの製造法および使用法
Document Type and Number:
Japanese Patent JP2001522597
Kind Code:
A
Abstract:
The invention relates to sophoroselipids of formula (I) wherein R4 represents H, -CH2CH3, -CH2CH2CH3, n is an integer number from 2 to 27, R1 and R2 represent, independently from each other, H or a group of formula (II), and R3 represents H or -OH. The invention also relates to a method for producing sophoroselipids of formula (I) wherein R1, R2, R3 and n have the aforementioned meanings and R4 represents -CH3, -CH2CH3 or -CH2CH2CH3. According to this method, a yeast capable of secreting a sophoroselipid in the form of a lactone in the culture excess, is fermented in a culture medium containing a glycerin. a succinate, a mono-, di- and/or tri-saccharide and a lipid precursor, said sophoroslipid being then isolated from the culture solution. The inventive method is characterised in that the lipid precursor contains one or more 3-alkanols, 4-alkanols or an alkanone with a chain length from 6 to 30 carbon atoms or mixtures of said alkanoistalkanone. Furthermore, according to a variant of the aforementioned method for producing sophoroselipids of formula (I), wherein R1, R2, R3 and n have the meanings aforementioned and R4 represents -CH3, -CH2CH3 or -CH2CH2CH3, the culture medium is maintained during fermentation under a reduced oxygen concentration. The new sophoroselipids may be used, e.g., as surfactants, cosmetics, disinfecting agents or pharmaceutical products.
Inventors:
Lang, Sigmund
Black meyer, andreas
Vulbrandt, Dieter
Seifert-Sterico, Andreas
Black meyer, andreas
Vulbrandt, Dieter
Seifert-Sterico, Andreas
Application Number:
JP2000520456A
Publication Date:
November 20, 2001
Filing Date:
October 17, 1998
Export Citation:
Assignee:
Aventis Research und Technologies Gaem Behr und Ko Kahge
International Classes:
A01N1/00; A01N43/16; A61K8/06; A61K8/60; A61K8/73; A61K31/70; C12P19/44; A61K47/26; A61L2/16; A61Q19/00; C07G3/00; C07H13/06; C07H15/04; C07H15/207; C11D1/66; C11D3/22; C12P19/46; C12R1/72; (IPC1-7): C12P19/44; A61K7/00; A61K47/26; C07H15/04
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)