Title:
【発明の名称】新規カルバメート基本カチオン性脂質
Document Type and Number:
Japanese Patent JPH11507352
Kind Code:
A
Abstract:
The present invention provides novel carbamate-based cationic lipids of the general structure: or a salt, or solvate, or enantiomers thereof wherein; (a) R1, is a lipophilic moiety; (b) R2 is a positively charged moiety; (c) n is an integer from 1 to 8; (d) X- is an anion or polyanion; and (e) m is an integer from 0 to a number equivalent to the positive charge(s) present on the lipid. The present invention further provides compositions of these lipids with polyanionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.
Inventors:
Schwartz, David Aaron
Brown, bob dale
Dwyer, brian patrick
Brown, bob dale
Dwyer, brian patrick
Application Number:
JP50185097A
Publication Date:
June 29, 1999
Filing Date:
June 05, 1996
Export Citation:
Assignee:
Jinta Incorporated
International Classes:
A61K9/127; A61K38/00; C07C271/20; C07D233/61; C07J9/00; C07J41/00; C07J43/00; C07J51/00; C07K5/02; (IPC1-7): C07J9/00; A61K9/127; A61K38/00; C07C271/20
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)